InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTP4A3

Summary

InnateDB Protein

IDBP-37457.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTP4A3

Protein Name

protein tyrosine phosphatase type IVA, member 3

Synonyms

PRL-3; PRL-R; PRL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000332274

InnateDB Gene

IDBG-37455 (PTP4A3)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269PubMed:11355880, ECO:0000269PubMed:12782572}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12782572}. Early endosome {ECO:0000269PubMed:12782572}.

Disease Associations

Tissue Specificity

Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269PubMed:11355880}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004727	prenylated protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt