InnateDB Protein
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IDBP-37459.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTP4A3
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Protein Name
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protein tyrosine phosphatase type IVA, member 3
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Synonyms
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PRL-3; PRL-R; PRL3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000331730
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InnateDB Gene
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IDBG-37455 (PTP4A3)
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Protein Structure
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Function |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269PubMed:11355880, ECO:0000269PubMed:12782572}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12782572}. Early endosome {ECO:0000269PubMed:12782572}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269PubMed:11355880}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
37
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004727
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prenylated protein tyrosine phosphatase activity
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GO:0016791
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phosphatase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000387
Protein-tyrosine/Dual specificity phosphatase
IPR029021
Protein-tyrosine phosphatase-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75365
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PhosphoSite |
PhosphoSite-O75365
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TrEMBL |
E5RGR3
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UniProt Splice Variant |
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Entrez Gene |
11156
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UniGene |
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RefSeq |
NP_009010
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HUGO |
HGNC:9636
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OMIM |
606449
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CCDS |
CCDS6382
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HPRD |
05922
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IMGT |
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EMBL |
AC100803
AF041434
AJ276554
BC003105
BT007303
U87168
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GenPept |
AAB47560
AAC29314
AAH03105
AAP35967
CAC81757
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