InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA4D

Summary

InnateDB Protein

IDBP-374808.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA4D

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Synonyms

C9orf164; CD100; coll-4; M-sema-G; SEMAJ;

Species

Homo sapiens

Ensembl Protein

ENSP00000391733

InnateDB Gene

IDBG-75424 (SEMA4D)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269PubMed:16055703, ECO:0000269PubMed:19788569, ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}; Single-pass type I membrane protein {ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}.

Disease Associations

Tissue Specificity

Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269PubMed:8876214}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001934	positive regulation of protein phosphorylation
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0010693	negative regulation of alkaline phosphatase activity
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335	positive regulation of cell migration
GO:0031344	regulation of cell projection organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0043066	negative regulation of apoptotic process
GO:0043931	ossification involved in bone maturation
GO:0045668	negative regulation of osteoblast differentiation
GO:0048672	positive regulation of collateral sprouting
GO:0048814	regulation of dendrite morphogenesis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0070486	leukocyte aggregation
GO:0071526	semaphorin-plexin signaling pathway
GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis