Version 5.4
Homo sapiens Gene: SEMA4D
Summary
InnateDB Gene IDBG-75424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA4D
Gene Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms C9orf164; CD100; coll-4; M-sema-G; SEMAJ
Species Homo sapiens
Ensembl Gene ENSG00000187764
Encoded Proteins
IDBP-75417
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-75428
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374808
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374810
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374812
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374814
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374816
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374818
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374825
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374828
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374830
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374832
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-374833
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-585220
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-588067
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89360787-89498130
Strand Reverse strand
Band q22.2
Transcripts
ENST00000339861 ENSP00000344923
ENST00000356444 ENSP00000348822
ENST00000420987 ENSP00000391733
ENST00000429836 ENSP00000395222
ENST00000420101 ENSP00000399948
ENST00000455551 ENSP00000411981
ENST00000450295 ENSP00000416523
ENST00000438547 ENSP00000405102
ENST00000422704 ENSP00000388768
ENST00000420681 ENSP00000390754
ENST00000433650 ENSP00000413352
ENST00000418828 ENSP00000416747
ENST00000420670 ENSP00000405652
ENST00000492386
ENST00000469653
ENST00000475255
ENST00000486935
ENST00000474258
ENST00000464051
ENST00000482128
ENST00000537934 ENSP00000446394
ENST00000540183
ENST00000544513
ENST00000540475 ENSP00000438389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001934 positive regulation of protein phosphorylation
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0031344 regulation of cell projection organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0043066 negative regulation of apoptotic process
GO:0043931 ossification involved in bone maturation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048672 positive regulation of collateral sprouting
GO:0048814 regulation of dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0070486 leukocyte aggregation
GO:0071526 semaphorin-plexin signaling pathway
GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021451
View Gene Order
ENSBTAG00000001941
Not yet available
Pathways
NETPATH
REACTOME
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.494406 Hs.601897
RefSeq NM_001142287 NM_006378 XM_005251654
HUGO
OMIM
CCDS CCDS47991 CCDS6685
HPRD 03520
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca