InnateDB Protein
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IDBP-374812.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEMA4D
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Protein Name
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sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
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Synonyms
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C9orf164; CD100; coll-4; M-sema-G; SEMAJ;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399948
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InnateDB Gene
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IDBG-75424 (SEMA4D)
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Protein Structure
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Function |
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA. {ECO:0000269PubMed:16055703, ECO:0000269PubMed:19788569, ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}; Single-pass type I membrane protein {ECO:0000269PubMed:20877282, ECO:0000269PubMed:8876214}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269PubMed:8876214}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001934
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positive regulation of protein phosphorylation
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GO:0006955
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immune response
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GO:0007155
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cell adhesion
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GO:0007162
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negative regulation of cell adhesion
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GO:0007411
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axon guidance
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GO:0008360
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regulation of cell shape
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GO:0010693
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negative regulation of alkaline phosphatase activity
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GO:0014068
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positive regulation of phosphatidylinositol 3-kinase signaling
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GO:0030335
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positive regulation of cell migration
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GO:0031344
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regulation of cell projection organization
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0043066
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negative regulation of apoptotic process
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GO:0043931
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ossification involved in bone maturation
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GO:0045668
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negative regulation of osteoblast differentiation
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GO:0048672
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positive regulation of collateral sprouting
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GO:0048814
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regulation of dendrite morphogenesis
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0050732
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negative regulation of peptidyl-tyrosine phosphorylation
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GO:0070486
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leukocyte aggregation
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GO:0071526
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semaphorin-plexin signaling pathway
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GO:1900220
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semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92854
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PhosphoSite |
PhosphoSite-Q92854
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10507
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UniGene |
Hs.601897
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RefSeq |
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HUGO |
HGNC:10732
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OMIM |
601866
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CCDS |
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HPRD |
03520
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IMGT |
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EMBL |
AK097056
AL590233
AL929575
BC054500
BC137515
BC137518
U60800
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GenPept |
AAC50810
AAH54500
AAI37516
AAI37519
BAC04938
CAI17379
CAI43250
CAI95794
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