InnateDB Protein
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IDBP-374831.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BRD2
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Protein Name
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bromodomain containing 2
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Synonyms
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D6S113E; FSH; FSRG1; NAT; RING3; RNF3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409145
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InnateDB Gene
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IDBG-81704 (BRD2)
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Protein Structure
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Function |
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269PubMed:18406326}.
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Subcellular Localization |
Nucleus {ECO:0000305}. Note=Detected on chromatin and nucleosomes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
|
Protein-Protein |
24
[view]
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Protein-DNA |
8
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
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PFAM |
PF00439
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
P25440
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PhosphoSite |
PhosphoSite-P25440
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TrEMBL |
X5CF57
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UniProt Splice Variant |
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Entrez Gene |
6046
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UniGene |
Hs.75243
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RefSeq |
NP_001186385
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HUGO |
HGNC:1103
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OMIM |
601540
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CCDS |
CCDS56421
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HPRD |
03326
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IMGT |
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EMBL |
AL645941
AL662845
AL805913
AL832722
AL935042
BC063840
BX005422
BX647233
BX648109
BX908719
CH471081
CR936909
D42040
KJ657694
KJ657695
KJ657696
KJ657697
M80613
X62083
X96670
Z96104
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GenPept |
AAA68890
AAH63840
AHW47930
AHW47947
AHW47964
AHW47981
BAA07641
CAA43996
CAA65450
CAC69989
CAH56171
CAH56179
CAH56208
EAX03662
EAX03663
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