Version 5.4
Homo sapiens Gene: BRD2
Summary
InnateDB Gene IDBG-81704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRD2
Gene Name bromodomain containing 2
Synonyms D6S113E; FSH; FSRG1; NAT; RING3; RNF3
Species Homo sapiens
Ensembl Gene ENSG00000204256
Encoded Proteins
IDBP-81706
bromodomain containing 2
IDBP-81708
bromodomain containing 2
IDBP-239843
bromodomain containing 2
IDBP-239845
bromodomain containing 2
IDBP-374817
bromodomain containing 2
IDBP-374831
bromodomain containing 2
IDBP-374838
bromodomain containing 2
IDBP-719030
IDBP-603279
bromodomain containing 2
IDBP-597258
bromodomain containing 2
IDBP-583204
bromodomain containing 2
IDBP-806602
bromodomain containing 2
IDBP-806604
bromodomain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32968660-32981505
Strand Forward strand
Band p21.32
Transcripts
ENST00000374831 ENSP00000363964
ENST00000374825 ENSP00000363958
ENST00000395289 ENSP00000378704
ENST00000395287 ENSP00000378702
ENST00000456339 ENSP00000411195
ENST00000449085 ENSP00000409145
ENST00000449025 ENSP00000409613
ENST00000496118 ENSP00000464077
ENST00000495733 ENSP00000436322
ENST00000482914 ENSP00000431514
ENST00000464592
ENST00000481259 ENSP00000433751
ENST00000463639
ENST00000469132
ENST00000482838
ENST00000580234
ENST00000581002
ENST00000584808
ENST00000607833 ENSP00000475691
ENST00000606059 ENSP00000475288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 24 [view]
Protein-DNA 8 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024335
View Gene Order
ENSBTAG00000011074
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 6046
UniGene
RefSeq NM_001113182 NM_001199455 NM_001199456 NM_001291986 NM_005104
HUGO HGNC:1103
OMIM 601540
CCDS CCDS4762 CCDS56420 CCDS56421
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 6046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca