InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HERC1

Summary

InnateDB Protein

IDBP-374886.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC1

Protein Name

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1

Synonyms

p532; p619;

Species

Homo sapiens

Ensembl Protein

ENSP00000390158

InnateDB Gene

IDBG-15997 (HERC1)

Protein Structure

UniProt Annotation

Function

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269PubMed:15642342, ECO:0000269PubMed:8861955, ECO:0000269PubMed:9233772}.

Subcellular Localization

Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin- rich surface protrusions.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8861955}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0006810	transport
GO:0010507	negative regulation of autophagy
GO:0016567	protein ubiquitination
GO:0021702	cerebellar Purkinje cell differentiation
GO:0031175	neuron projection development
GO:0043547	positive regulation of GTPase activity
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR001680 WD40 repeat
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009060 UBA-like
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PF00415
PF00632
PF00400
PF00622

PRINTS

PR00633

PIRSF

SMART

SM00119
SM00320
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt