Version 5.4
Homo sapiens Gene: HERC1
Summary
InnateDB Gene IDBG-15997.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC1
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms p532; p619
Species Homo sapiens
Ensembl Gene ENSG00000103657
Encoded Proteins
IDBP-374886
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-590365
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-594557
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-588697
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-585453
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-592376
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-584657
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-601811
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
IDBP-602066
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:63608618-63833942
Strand Reverse strand
Band q22.31
Transcripts
ENST00000443617 ENSP00000390158
ENST00000559996
ENST00000558324 ENSP00000453196
ENST00000561348
ENST00000561436
ENST00000561359 ENSP00000453603
ENST00000560897 ENSP00000452671
ENST00000559715 ENSP00000452654
ENST00000561400 ENSP00000453937
ENST00000560983
ENST00000560519
ENST00000559886
ENST00000558532 ENSP00000453086
ENST00000560462 ENSP00000452969
ENST00000560316 ENSP00000453010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0006810 transport
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0021702 cerebellar Purkinje cell differentiation
GO:0031175 neuron projection development
GO:0043547 positive regulation of GTPase activity
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038664
View Gene Order
ENSBTAG00000019474
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.210385 Hs.644993
RefSeq NM_003922 XM_005254742 XM_005254743 XM_005254746 XM_005254747
HUGO
OMIM
CCDS CCDS45277
HPRD 06894
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca