InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMED7

Summary

InnateDB Protein

IDBP-374898.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMED7

Protein Name

transmembrane emp24 protein transport domain containing 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000405926

InnateDB Gene

IDBG-37819 (TMED7)

Protein Structure

UniProt Annotation

Function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006810	transport
GO:0015031	protein transport
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030126	COPI vesicle coat
GO:0030127	COPII vesicle coat
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome