Version 5.4
| Homo sapiens Gene: TMED7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-37819.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TMED7 | ||||||||||||||||||
| Gene Name | transmembrane emp24 protein transport domain containing 7 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000134970 | ||||||||||||||||||
| Encoded Proteins |
transmembrane emp24 protein transport domain containing 7
transmembrane emp24 protein transport domain containing 7
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
TMED7;TICAM2 (TICAM2) splice variant TAG negatively regulates the adapter MYD88-independent TLR4 pathway by displacing TICAM1 adapter from TICAM2.
TICAM2 and TICAM1 both function in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to lipopolysaccharide (LPS).
TICAM2 and TICAM1 form an adapter complex that plays a crucial role for LPS-TLR4-mediated activation of IFN-beta.
TMED7;TICAM2 is an adapter protein for both TLR4 and TLR2/6 signaling in synovial fibroblasts, HUVECs, and murine embryonic fibroblasts.
TICAM2 provides specificity for the MYD88-independent component of TLR4 signalling.
TMED7 inhibits LPS-mediated TLR4 signalling in late endosomes.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Tmed7 inhibits LPS-mediated Tlr4 signalling in late endosomes. (Demonstrated in human)
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| Entrez Gene | |||||||||||||||||||
| Summary |
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 5:115613508-115632992 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q22.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | G3V2Y2 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 51014 | ||||||||||||||||||
| UniGene | Hs.642817 Hs.743391 | ||||||||||||||||||
| RefSeq | NM_181836 | ||||||||||||||||||
| HUGO | HGNC:24253 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS4120 | ||||||||||||||||||
| HPRD | 13029 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC010226 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 100302736 51014 | ||||||||||||||||||