Version 5.4
Homo sapiens Protein: ARHGAP22
Summary
InnateDB Protein IDBP-375061.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP22
Protein Name Rho GTPase activating protein 22
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000416701
InnateDB Gene IDBG-73661 (ARHGAP22)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0030154 cell differentiation
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00169
PRINTS
PIRSF
SMART SM00324
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z5H3
PhosphoSite PhosphoSite-Q7Z5H3
TrEMBL
UniProt Splice Variant
Entrez Gene 58504
UniGene Hs.690354
RefSeq NP_001242954
HUGO HGNC:30320
OMIM 610585
CCDS CCDS58081
HPRD 12476
IMGT
EMBL AC016397 AC016399 AC068898 AK127586 AK293579 AY324801 BC126444 BC136319 CH471187 EF560749 U90908
GenPept AAB51057 AAI26445 AAI36320 AAP85632 ABQ59059 BAC87044 BAG57049 EAW93127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca