InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2A1

Summary

InnateDB Protein

IDBP-375139.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2A1

Protein Name

general transcription factor IIA, 1, 19/37kDa

Synonyms

TF2A1; TFIIA; TFIIA-42; TFIIAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000409492

InnateDB Gene

IDBG-14595 (GTF2A1)

Protein Structure

UniProt Annotation

Function

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269PubMed:11030333, ECO:0000269PubMed:16537915}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process