Version 5.4
Homo sapiens Protein: PARP16
Summary
InnateDB Protein IDBP-375252.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP16
Protein Name poly (ADP-ribose) polymerase family, member 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000396118
InnateDB Gene IDBG-17194 (PARP16)
Protein Structure
UniProt Annotation
Function Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. {ECO:0000269PubMed:22701565, ECO:0000269PubMed:23103912}.
Subcellular Localization Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0060548 negative regulation of cell death
GO:0070213 protein auto-ADP-ribosylation
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0071782 endoplasmic reticulum tubular network
Protein Structure and Domains
PDB ID
InterPro IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF00644
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N5Y8
PhosphoSite PhosphoSite-Q8N5Y8
TrEMBL A0A024R5Y7
UniProt Splice Variant
Entrez Gene 54956
UniGene Hs.618971
RefSeq
HUGO HGNC:26040
OMIM
CCDS
HPRD 07919
IMGT
EMBL AK000516 BC006389 BC031074 CH471082
GenPept AAH06389 AAH31074 BAA91222 EAW77718 EAW77720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca