InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNN2

Summary

InnateDB Protein

IDBP-37539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNN2

Protein Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Synonyms

hSK2; KCa2.2; SK2; SKCa 2; SKCA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264773

InnateDB Gene

IDBG-37535 (KCNN2)

Protein Structure

UniProt Annotation

Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269PubMed:13679367}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0042803	protein homodimerization activity
GO:0051393	alpha-actinin binding

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0071805	potassium ion transmembrane transport
GO:1901379	regulation of potassium ion transmembrane transport