Version 5.4
Homo sapiens Protein: VPS52
Summary
InnateDB Protein IDBP-375418.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS52
Protein Name vacuolar protein sorting 52 homolog (S. cerevisiae)
Synonyms ARE1; dJ1033B10.5; SAC2; SACM2L;
Species Homo sapiens
Ensembl Protein ENSP00000409952
InnateDB Gene IDBG-304142 (VPS52)
Protein Structure
UniProt Annotation
Function May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269PubMed:15878329, ECO:0000269PubMed:18367545}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010668 ectodermal cell differentiation
GO:0015031 protein transport
GO:0048611 embryonic ectodermal digestive tract development
Cellular Component
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR007258 Vps52/Sac2
IPR019160 Exocyst complex, component 1/SEC3
PFAM PF04129
PF09763
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N1B4
PhosphoSite PhosphoSite-Q8N1B4
TrEMBL B4DS44
UniProt Splice Variant
Entrez Gene 6293
UniGene Hs.480356
RefSeq NP_072047
HUGO HGNC:10518
OMIM 603443
CCDS CCDS4770
HPRD 09142
IMGT
EMBL AK222867 AK297935 AK299563 AL031228 AL390171 AL645940 BC032108 BC040114 BX248408 CH471081 CR759786 CR759817 CR762434
GenPept AAH32108 AAH40114 BAD96587 BAG60251 BAG61506 CAB99099 CAI95619 CAM26258 CAQ06872 CAQ08020 CAQ08250 EAX03688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca