Homo sapiens Gene: VPS52
Summary
InnateDB Gene IDBG-304142.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS52
Gene Name vacuolar protein sorting 52 homolog (S. cerevisiae)
Synonyms ARE1; dJ1033B10.5; SAC2; SACM2L
Species Homo sapiens
Ensembl Gene ENSG00000223501
Encoded Proteins
vacuolar protein sorting 52 homolog (S. cerevisiae)
vacuolar protein sorting 52 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33250272-33272047
Strand Reverse strand
Band p21.32
Transcripts
ENST00000445902 ENSP00000409952
ENST00000482399 ENSP00000436612
ENST00000478934
ENST00000495981
ENST00000493674
ENST00000471309
ENST00000461743
ENST00000493379
ENST00000495755
ENST00000463486
ENST00000464425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010668 ectodermal cell differentiation
GO:0015031 protein transport
GO:0048611 embryonic ectodermal digestive tract development
Cellular Component
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480356
RefSeq NM_001289174 NM_001289175 NM_022553 XM_006715163
HUGO
OMIM
CCDS CCDS4770
HPRD 09142
IMGT
EMBL
GenPept
RNA Seq Atlas