InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX30

Summary

InnateDB Protein

IDBP-375483.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX30

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 30

Synonyms

DDX30; RETCOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000394682

InnateDB Gene

IDBG-31963 (DHX30)

Protein Structure

UniProt Annotation

Function

Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA. {ECO:0000250, ECO:0000269PubMed:16825194}.

Subcellular Localization

Isoform 2: Cytoplasm.Isoform 1: Cytoplasm.Mitochondrion. Cytoplasm {ECO:0000305}. Mitochondrion matrix, mitochondrion nucleoid.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200

ATP catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7L2E3