Version 5.4
Homo sapiens Gene: DHX30
Summary
InnateDB Gene IDBG-31963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX30
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 30
Synonyms DDX30; RETCOR
Species Homo sapiens
Ensembl Gene ENSG00000132153
Encoded Proteins
IDBP-31965
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-238898
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-375461
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-375462
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-375470
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-375476
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-375483
DEAH (Asp-Glu-Ala-His) box polypeptide 30
IDBP-810491
DEAH (Asp-Glu-Ala-His) box helicase 30
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:47802909-47850195
Strand Forward strand
Band p21.31
Transcripts
ENST00000348968 ENSP00000343442
ENST00000395745 ENSP00000379094
ENST00000445061 ENSP00000405620
ENST00000415400 ENSP00000395166
ENST00000441384 ENSP00000410571
ENST00000446256 ENSP00000392601
ENST00000457607 ENSP00000394682
ENST00000472718
ENST00000476446
ENST00000492893
ENST00000471082
ENST00000470959
ENST00000461905
ENST00000474183
ENST00000619982 ENSP00000483160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003682 chromatin binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032480
View Gene Order
ENSBTAG00000015833
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517948 Hs.739525
RefSeq NM_014966 NM_138615 XM_006713032 XM_006713033
HUGO
OMIM
CCDS CCDS2759
HPRD 13142
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca