InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLE1

Summary

InnateDB Protein

IDBP-375487.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLE1

Protein Name

notchless homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413572

InnateDB Gene

IDBG-41378 (NLE1)

Protein Structure

UniProt Annotation

Function

Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269Ref.5}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001826	inner cell mass cell differentiation
GO:0007219	Notch signaling pathway
GO:0042273	ribosomal large subunit biogenesis
GO:0045930	negative regulation of mitotic cell cycle
GO:0061484	hematopoietic stem cell homeostasis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway