InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CITED1

Summary

InnateDB Protein

IDBP-375743.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CITED1

Protein Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

Synonyms

MSG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000403274

InnateDB Gene

IDBG-76674 (CITED1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269PubMed:10722728, ECO:0000269PubMed:11581164, ECO:0000269PubMed:21172805}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16864582}. Cytoplasm {ECO:0000269PubMed:16864582}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.

Disease Associations

Tissue Specificity

Expressed only in melanocytes and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0050693	LBD domain binding
GO:0070410	co-SMAD binding

Biological Process

GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008283	cell proliferation
GO:0010628	positive regulation of gene expression
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030318	melanocyte differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032868	response to insulin
GO:0034097	response to cytokine
GO:0034341	response to interferon-gamma
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0043524	negative regulation of neuron apoptotic process
GO:0043627	response to estrogen
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051591	response to cAMP
GO:0060231	mesenchymal to epithelial transition
GO:0060395	SMAD protein signal transduction
GO:0070555	response to interleukin-1
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0070741	response to interleukin-6
GO:0071104	response to interleukin-9
GO:0071105	response to interleukin-11
GO:0071107	response to parathyroid hormone
GO:0071559	response to transforming growth factor beta