Version 5.4
Homo sapiens Gene: CITED1
Summary
InnateDB Gene IDBG-76674.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CITED1
Gene Name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Synonyms MSG1
Species Homo sapiens
Ensembl Gene ENSG00000125931
Encoded Proteins
IDBP-76676
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-76678
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375739
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375743
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375745
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375749
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375752
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375757
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375762
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
IDBP-375766
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:72301638-72307187
Strand Reverse strand
Band q13.1
Transcripts
ENST00000373619 ENSP00000362721
ENST00000246139 ENSP00000246139
ENST00000431381 ENSP00000388548
ENST00000445983 ENSP00000403274
ENST00000429794 ENSP00000407496
ENST00000417400 ENSP00000414781
ENST00000427412 ENSP00000391407
ENST00000453707 ENSP00000401764
ENST00000450875 ENSP00000405765
ENST00000454225 ENSP00000412769
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 14 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0050693 LBD domain binding
GO:0070410 co-SMAD binding
Biological Process
GO:0000578 embryonic axis specification
GO:0001570 vasculogenesis
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001890 placenta development
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030318 melanocyte differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0034097 response to cytokine
GO:0034341 response to interferon-gamma
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051591 response to cAMP
GO:0060231 mesenchymal to epithelial transition
GO:0060395 SMAD protein signal transduction
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:0070555 response to interleukin-1
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070741 response to interleukin-6
GO:0071104 response to interleukin-9
GO:0071105 response to interleukin-11
GO:0071107 response to parathyroid hormone
GO:0071559 response to transforming growth factor beta
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051159
View Gene Order
ENSBTAG00000045925
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL C9JRD8
UniProt Splice Variant
Entrez Gene 4435
UniGene Hs.40403
RefSeq NM_001144885 NM_001144886 NM_001144887 NM_004143 XM_005262267
HUGO HGNC:1986
OMIM 300149
CCDS CCDS14419 CCDS48136
HPRD 02146
IMGT
EMBL AL135749
GenPept
RNA Seq Atlas 4435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca