InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSPH

Summary

InnateDB Protein

IDBP-375964.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSPH

Protein Name

phosphoserine phosphatase

Synonyms

PSP; PSPHD;

Species

Homo sapiens

Ensembl Protein

ENSP00000401639

InnateDB Gene

IDBG-17389 (PSPH)

Protein Structure

UniProt Annotation

Function

Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. {ECO:0000269PubMed:12777757}.

Subcellular Localization

Disease Associations

Phosphoserine phosphatase deficiency (PSPHD) [MIM:614023]: A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. {ECO:0000269PubMed:14673469}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004647	phosphoserine phosphatase activity
GO:0005509	calcium ion binding
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0016311	dephosphorylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR004469 Phosphoserine phosphatase SerB
IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR006434 Pyrimidine 5\'-nucleotidase, eukaryotic
IPR016965 Phosphatase PHOSPHO-type
IPR023214 HAD-like domain

PFAM

PF05822
PF06888
PF00702
PF08282
PF13419

PRINTS

PIRSF

PIRSF031051

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P78330