Version 5.4
Homo sapiens Protein: SHISA5
Summary
InnateDB Protein IDBP-376046.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHISA5
Protein Name shisa homolog 5 (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000407957
InnateDB Gene IDBG-32953 (SHISA5)
Protein Structure
UniProt Annotation
Function Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. {ECO:0000269PubMed:12135983}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12135983}; Single-pass type I membrane protein {ECO:0000269PubMed:12135983}. Nucleus membrane {ECO:0000269PubMed:12135983}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N114
PhosphoSite PhosphoSite-Q8N114
TrEMBL C9IZ46
UniProt Splice Variant
Entrez Gene 51246
UniGene Hs.739088
RefSeq NP_001258995
HUGO HGNC:30376
OMIM 607290
CCDS CCDS63622
HPRD 06290
IMGT
EMBL AB097007 AC104448 AC134772 AF520698 AH011688 AK056328 AK075441 AK124652 AK301191 AL117413 AL832568 BC001463 CH471055
GenPept AAH01463 AAM74232 AAM74235 BAB71152 BAC11623 BAC77360 BAG54061 BAH13428 CAH10587 CAH10718 EAW64885 EAW64886 EAW64887 EAW64889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca