Version 5.4
Homo sapiens Gene: SHISA5
Summary
InnateDB Gene IDBG-32953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHISA5
Gene Name shisa homolog 5 (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164054
Encoded Proteins
IDBP-32955
shisa homolog 5 (Xenopus laevis)
IDBP-376046
shisa homolog 5 (Xenopus laevis)
IDBP-376048
shisa homolog 5 (Xenopus laevis)
IDBP-376049
shisa homolog 5 (Xenopus laevis)
IDBP-376050
shisa homolog 5 (Xenopus laevis)
IDBP-376056
shisa homolog 5 (Xenopus laevis)
IDBP-376057
shisa homolog 5 (Xenopus laevis)
IDBP-376058
shisa homolog 5 (Xenopus laevis)
IDBP-376059
shisa homolog 5 (Xenopus laevis)
IDBP-376061
shisa homolog 5 (Xenopus laevis)
IDBP-810359
shisa family member 5
IDBP-810365
shisa family member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48467798-48504826
Strand Reverse strand
Band p21.31
Transcripts
ENST00000296444 ENSP00000296444
ENST00000444115 ENSP00000407957
ENST00000426002 ENSP00000390388
ENST00000442747 ENSP00000408223
ENST00000417962 ENSP00000407330
ENST00000443308 ENSP00000395373
ENST00000424965 ENSP00000412811
ENST00000417841 ENSP00000412509
ENST00000415268 ENSP00000400498
ENST00000441507 ENSP00000415097
ENST00000466424
ENST00000494854
ENST00000465449
ENST00000460758
ENST00000497863
ENST00000486344
ENST00000490864
ENST00000496408
ENST00000619810 ENSP00000484992
ENST00000612611 ENSP00000482723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025647
View Gene Order
ENSBTAG00000009183
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.414579 Hs.664265 Hs.719070 Hs.739088
RefSeq NM_001272065 NM_001272066 NM_001272067 NM_001272068 NM_001272082 NM_001272083 NM_016479
HUGO
OMIM
CCDS CCDS2770 CCDS63621 CCDS63622 CCDS63623
HPRD 06290
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca