InnateDB Protein
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IDBP-376203.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CERS1
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Protein Name
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ceramide synthase 1
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Synonyms
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DORV; DTGA3; LAG1; LASS1; RAI; UOG1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389044
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InnateDB Gene
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IDBG-304491 (CERS1)
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Protein Structure
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Function |
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.Isoform 1: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006634
TRAM/LAG1/CLN8 homology domain
IPR016439
Longevity assurance, LAG1/LAC1
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PFAM |
PF03798
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PRINTS |
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PIRSF |
PIRSF005225
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SMART |
SM00724
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TIGRFAMs |
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Modification |
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SwissProt |
P27544
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PhosphoSite |
PhosphoSite-P27544
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TrEMBL |
Q5XG75
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UniProt Splice Variant |
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Entrez Gene |
2657
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UniGene |
Hs.412355
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RefSeq |
NP_937850
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HUGO |
HGNC:14253
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OMIM |
606919
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CCDS |
CCDS46021
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HPRD |
12114
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IMGT |
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EMBL |
AC003972
AC005197
AF105005
AF105006
AF105007
AF105008
AF105009
BC022450
BC084582
M62302
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GenPept |
AAA58500
AAC24611
AAD16892
AAH22450
AAH84582
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