InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CERS1

Summary

InnateDB Gene

IDBG-304491.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CERS1

Gene Name

ceramide synthase 1

Synonyms

DORV; DTGA3; LAG1; LASS1; RAI; UOG1

Species

Homo sapiens

Ensembl Gene

ENSG00000223802

Encoded Proteins

IDBP-376203

ceramide synthase 1

IDBP-583287

ceramide synthase 1

IDBP-760951

IDBP-808389

ceramide synthase 1

IDBP-808401

ceramide synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008] This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Mar 2014]
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18868545-18896727

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000429504	ENSP00000389044
ENST00000542296	ENSP00000437648
ENST00000596048	ENSP00000471428
ENST00000623882	ENSP00000485308
ENST00000623927	ENSP00000485582

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0035690	cellular response to drug
GO:0036146	cellular response to mycotoxin
GO:0040007	growth
GO:0044281	small molecule metabolic process
GO:0046513	ceramide biosynthetic process
GO:0051974	negative regulation of telomerase activity
GO:0071492	cellular response to UV-A
GO:0072721	cellular response to dithiothreitol

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000087408

View Gene Order

ENSBTAG00000037729

Not yet available

Pathways

NETPATH

REACTOME

REACT_115810

Sphingolipid de novo biosynthesis pathway

REACT_19323

Sphingolipid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00600

Sphingolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.412355

RefSeq

NM_001290265 NM_001492 NM_021267 NM_198207

HUGO

OMIM

CCDS

CCDS42526 CCDS46021

HPRD

12114

IMGT

EMBL

GenPept

RNA Seq Atlas