InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IP6K2

Summary

InnateDB Protein

IDBP-376491.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IP6K2

Protein Name

inositol hexakisphosphate kinase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387759

InnateDB Gene

IDBG-33661 (IP6K2)

Protein Structure

UniProt Annotation

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. {ECO:0000269PubMed:10574768}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11502751}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030308	negative regulation of cell growth
GO:0043065	positive regulation of apoptotic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0060337	type I interferon signaling pathway