Version 5.4
Homo sapiens Gene: IP6K2
Summary
InnateDB Gene IDBG-33661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IP6K2
Gene Name inositol hexakisphosphate kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000068745
Encoded Proteins
IDBP-33663
inositol hexakisphosphate kinase 2
IDBP-33665
inositol hexakisphosphate kinase 2
IDBP-376479
inositol hexakisphosphate kinase 2
IDBP-376480
inositol hexakisphosphate kinase 2
IDBP-376481
inositol hexakisphosphate kinase 2
IDBP-376482
inositol hexakisphosphate kinase 2
IDBP-376483
inositol hexakisphosphate kinase 2
IDBP-376485
inositol hexakisphosphate kinase 2
IDBP-376486
inositol hexakisphosphate kinase 2
IDBP-376487
inositol hexakisphosphate kinase 2
IDBP-376491
inositol hexakisphosphate kinase 2
IDBP-376494
inositol hexakisphosphate kinase 2
IDBP-376497
inositol hexakisphosphate kinase 2
IDBP-376498
inositol hexakisphosphate kinase 2
IDBP-376500
inositol hexakisphosphate kinase 2
IDBP-376502
inositol hexakisphosphate kinase 2
IDBP-376504
inositol hexakisphosphate kinase 2
IDBP-376505
inositol hexakisphosphate kinase 2
IDBP-376508
inositol hexakisphosphate kinase 2
IDBP-376511
inositol hexakisphosphate kinase 2
IDBP-376516
inositol hexakisphosphate kinase 2
IDBP-376518
inositol hexakisphosphate kinase 2
IDBP-376521
inositol hexakisphosphate kinase 2
IDBP-376522
inositol hexakisphosphate kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48688003-48740353
Strand Reverse strand
Band p21.31
Transcripts
ENST00000328631 ENSP00000331103
ENST00000340879 ENSP00000341925
ENST00000449563 ENSP00000411776
ENST00000413654 ENSP00000414428
ENST00000443853 ENSP00000389761
ENST00000437427 ENSP00000403968
ENST00000412850 ENSP00000395819
ENST00000454335 ENSP00000412121
ENST00000432678 ENSP00000400812
ENST00000433104 ENSP00000396904
ENST00000416707 ENSP00000387759
ENST00000431721 ENSP00000414139
ENST00000449610 ENSP00000393077
ENST00000413298 ENSP00000396203
ENST00000450045 ENSP00000394488
ENST00000446860 ENSP00000399052
ENST00000455545 ENSP00000410454
ENST00000412795 ENSP00000389755
ENST00000417896 ENSP00000388116
ENST00000443964 ENSP00000410950
ENST00000436134
ENST00000453202 ENSP00000387394
ENST00000440424 ENSP00000393797
ENST00000434860 ENSP00000388420
ENST00000424035 ENSP00000406357
ENST00000479914
ENST00000491686
ENST00000476645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
Biological Process
GO:0006817 phosphate ion transport
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032599
View Gene Order
ENSBTAG00000021853
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_150275
Synthesis of IPs in the nucleus pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595983 Hs.711296 Hs.739299
RefSeq NM_001005909 NM_001005910 NM_001005911 NM_001146178 NM_001146179 NM_001190316 NM_001190317 NM_016291 XM_006713199 XM_006713200 XM_006713201 XM_006713202
HUGO
OMIM
CCDS CCDS2777 CCDS33752 CCDS54579 CCDS54580 CCDS54581
HPRD 07380
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca