InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCOCO1

Summary

InnateDB Protein

IDBP-376611.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCOCO1

Protein Name

calcium binding and coiled-coil domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397189

InnateDB Gene

IDBG-37186 (CALCOCO1)

Protein Structure

UniProt Annotation

Function

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). {ECO:0000250}.Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269Ref.1}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated