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InnateDB Protein
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IDBP-376782.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NUDC
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Protein Name
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nuclear distribution gene C homolog (A. nidulans)
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Synonyms
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HNUDC; MNUDC; NPD011;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000404020
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InnateDB Gene
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IDBG-94765 (NUDC)
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Protein Structure
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| Function |
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. {ECO:0000250, ECO:0000269PubMed:12679384, ECO:0000269PubMed:12852857}.
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| Subcellular Localization |
Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. {ECO:0000269PubMed:10210332, ECO:0000269PubMed:10453739}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
127
[view]
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| Protein-Protein |
127
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
3 [view]
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| PDB ID |
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| InterPro |
IPR008978
HSP20-like chaperone
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9Y266
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
10726
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| UniGene |
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| RefSeq |
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| HUGO |
HGNC:8045
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| OMIM |
610325
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| CCDS |
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| HPRD |
10122
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4