InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QARS

Summary

InnateDB Protein

IDBP-376884.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QARS

Protein Name

glutaminyl-tRNA synthetase

Synonyms

GLNRS; MSCCA; PRO2195;

Species

Homo sapiens

Ensembl Protein

ENSP00000390015

InnateDB Gene

IDBG-34287 (QARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.

Experimentally validated
Total	120 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004819	glutamine-tRNA ligase activity
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006425	glutaminyl-tRNA aminoacylation
GO:0010467	gene expression
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000924 Glutamyl/glutaminyl-tRNA synthetase
IPR004514 Glutamine-tRNA synthetase
IPR007638 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
IPR007639 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain

PFAM

PF04557
PF04558
PF00749
PF03950

PRINTS

PR00987

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47897