InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHF1

Summary

InnateDB Protein

IDBP-376953.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHF1

Protein Name

pleckstrin homology domain containing, family F (with FYVE domain) member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000389787

InnateDB Gene

IDBG-41768 (PLEKHF1)

Protein Structure

UniProt Annotation

Function

May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269PubMed:16188880}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269PubMed:16188880}. Lysosome {ECO:0000269PubMed:16188880}. Note=Translocates to lysosome during apoptosis.

Disease Associations

Tissue Specificity

Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269PubMed:16188880}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0046872	metal ion binding
GO:0070273	phosphatidylinositol-4-phosphate binding

Biological Process

GO:0006915	apoptotic process
GO:0007032	endosome organization
GO:0010508	positive regulation of autophagy
GO:0016050	vesicle organization
GO:0072659	protein localization to plasma membrane
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway