Version 5.4
Homo sapiens Gene: PLEKHF1
Summary
InnateDB Gene IDBG-41768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHF1
Gene Name pleckstrin homology domain containing, family F (with FYVE domain) member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166289
Encoded Proteins
IDBP-376953
pleckstrin homology domain containing, family F (with FYVE domain) member 1
IDBP-765109
IDBP-762237
IDBP-765194
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:29665056-29675457
Strand Forward strand
Band q12
Transcripts
ENST00000436066 ENSP00000389787
ENST00000588833 ENSP00000464925
ENST00000592810 ENSP00000466292
ENST00000586888 ENSP00000466003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0006915 apoptotic process
GO:0007032 endosome organization
GO:0010508 positive regulation of autophagy
GO:0016050 vesicle organization
GO:0072659 protein localization to plasma membrane
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074170
View Gene Order
ENSBTAG00000008625
Not yet available
Cross-References
SwissProt
TrEMBL K7EIX0 K7ELB8
UniProt Splice Variant
Entrez Gene 79156
UniGene Hs.466383
RefSeq NM_024310
HUGO HGNC:20764
OMIM 615200
CCDS CCDS12417
HPRD 15146
IMGT
EMBL AC010512 AC010644
GenPept
RNA Seq Atlas 79156

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca