Homo sapiens Protein: APOBEC3H | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-377059.5 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | APOBEC3H | ||||||||||||||
Protein Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H | ||||||||||||||
Synonyms | |||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Protein | ENSP00000411754 | ||||||||||||||
InnateDB Gene | IDBG-8048 (APOBEC3H) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H- var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269PubMed:16571802, ECO:0000269PubMed:16920826, ECO:0000269PubMed:18299330, ECO:0000269PubMed:18779051, ECO:0000269PubMed:18827027, ECO:0000269PubMed:20062055, ECO:0000269PubMed:21835787, ECO:0000269PubMed:22457529, ECO:0000269PubMed:22915799, ECO:0000269PubMed:23097438}. | ||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin. {ECO:0000269PubMed:16571802, ECO:0000269PubMed:20308164}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR002125
CMP/dCMP deaminase, zinc-binding IPR007904 APOBEC-like, C-terminal IPR013158 APOBEC-like, N-terminal IPR016193 Cytidine deaminase-like |
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PFAM |
PF00383
PF05240 PF08210 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q6NTF7 | ||||||||||||||
PhosphoSite | PhosphoSite-Q6NTF7 | ||||||||||||||
TrEMBL | B7TQM3 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 164668 | ||||||||||||||
UniGene | Hs.440515 | ||||||||||||||
RefSeq | NP_861438 | ||||||||||||||
HUGO | HGNC:24100 | ||||||||||||||
OMIM | 610976 | ||||||||||||||
CCDS | CCDS13985 | ||||||||||||||
HPRD | 16508 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AL031846 BC069023 BQ052182 CR456481 FJ376611 FJ376613 | ||||||||||||||
GenPept | AAH69023 ACK77772 ACK77774 CAG30367 | ||||||||||||||