Version 5.4
Homo sapiens Gene: APOBEC3H
Summary
InnateDB Gene IDBG-8048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3H
Gene Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100298
Encoded Proteins
IDBP-8050
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
IDBP-292757
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
IDBP-377059
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
IDBP-377065
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
IDBP-809813
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
IDBP-809815
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39097224-39104067
Strand Forward strand
Band q13.1
Transcripts
ENST00000348946 ENSP00000216123
ENST00000401756 ENSP00000385741
ENST00000442487 ENSP00000411754
ENST00000421988 ENSP00000393520
ENST00000474235
ENST00000613996 ENSP00000482682
ENST00000613677 ENSP00000483689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0009972 cytidine deamination
GO:0010529 negative regulation of transposition
GO:0045087 innate immune response
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0048525 negative regulation of viral process
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q6NTF7
TrEMBL B7TQM3
UniProt Splice Variant
Entrez Gene 164668
UniGene Hs.440515
RefSeq NM_181773 NM_001166002 NM_001166003 NM_001166004
HUGO HGNC:24100
OMIM 610976
CCDS CCDS13985 CCDS54530 CCDS54531 CCDS54532
HPRD 16508
IMGT
EMBL AL031846 BC069023 BQ052182 CR456481 FJ376611 FJ376613
GenPept AAH69023 ACK77772 ACK77774 CAG30367
RNA Seq Atlas 164668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca