InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IKZF3

Summary

InnateDB Protein

IDBP-377362.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IKZF3

Protein Name

IKAROS family zinc finger 3 (Aiolos)

Synonyms

AIO; AIOLOS; ZNFN1A3;

Species

Homo sapiens

Ensembl Protein

ENSP00000403027

InnateDB Gene

IDBG-46313 (IKZF3)

Protein Structure

UniProt Annotation

Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner. {ECO:0000269PubMed:10369681}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. {ECO:0000269PubMed:17646674}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007498	mesoderm development
GO:0030888	regulation of B cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0045577	regulation of B cell differentiation
GO:0045619	regulation of lymphocyte differentiation