Version 5.4
Homo sapiens Gene: IKZF3
Summary
InnateDB Gene IDBG-46313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKZF3
Gene Name IKAROS family zinc finger 3 (Aiolos)
Synonyms AIO; AIOLOS; ZNFN1A3
Species Homo sapiens
Ensembl Gene ENSG00000161405
Encoded Proteins
IDBP-758304
IDBP-46317
IKAROS family zinc finger 3 (Aiolos)
IDBP-46319
IKAROS family zinc finger 3 (Aiolos)
IDBP-762897
IDBP-46323
IKAROS family zinc finger 3 (Aiolos)
IDBP-46325
IKAROS family zinc finger 3 (Aiolos)
IDBP-46327
IKAROS family zinc finger 3 (Aiolos)
IDBP-46329
IKAROS family zinc finger 3 (Aiolos)
IDBP-46331
IKAROS family zinc finger 3 (Aiolos)
IDBP-46333
IKAROS family zinc finger 3 (Aiolos)
IDBP-242078
IKAROS family zinc finger 3 (Aiolos)
IDBP-377359
IKAROS family zinc finger 3 (Aiolos)
IDBP-377362
IKAROS family zinc finger 3 (Aiolos)
IDBP-485569
IKAROS family zinc finger 3 (Aiolos)
IDBP-587417
IKAROS family zinc finger 3 (Aiolos)
IDBP-761448
IDBP-806946
IKAROS family zinc finger 3 (Aiolos)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39757721-39864188
Strand Reverse strand
Band q21.1
Transcripts
ENST00000293068 ENSP00000462791
ENST00000350532 ENSP00000344471
ENST00000351680 ENSP00000345622
ENST00000348427 ENSP00000463505
ENST00000346243 ENSP00000341977
ENST00000377958 ENSP00000367194
ENST00000346872 ENSP00000344544
ENST00000377952 ENSP00000367188
ENST00000377945 ENSP00000367180
ENST00000377944 ENSP00000367179
ENST00000394189 ENSP00000377741
ENST00000439167 ENSP00000403776
ENST00000439016 ENSP00000403027
ENST00000467757 ENSP00000420463
ENST00000535189 ENSP00000438972
ENST00000583368 ENSP00000462452
ENST00000623724 ENSP00000485515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007498 mesoderm development
GO:0030888 regulation of B cell proliferation
GO:0042113 B cell activation
GO:0042981 regulation of apoptotic process
GO:0045577 regulation of B cell differentiation
GO:0045619 regulation of lymphocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018168
View Gene Order
ENSBTAG00000011003
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
il2_1pathway
IL2-mediated signaling events
Cross-References
SwissProt Q9UKT9
TrEMBL
UniProt Splice Variant
Entrez Gene 22806
UniGene
RefSeq NM_183228 NM_001257408 NM_001257409 NM_001257410 NM_001257411 NM_001257412 NM_001257413 NM_001257414 NM_001284514 NM_001284515 NM_001284516 NM_012481 NM_183229 NM_183230 NM_183231 NM_183232
HUGO HGNC:13178
OMIM 606221
CCDS CCDS11347 CCDS11346 CCDS11348 CCDS11349 CCDS11350 CCDS11351 CCDS58539 CCDS58540 CCDS58541 CCDS58542 CCDS58543 CCDS58544 CCDS58545 CCDS74055
HPRD 05869
IMGT
EMBL AC079199 AC090844 AF129512 AJ292565 AJ292566 AJ292567 AJ292568 AJ292569 AK301250 AK303495 AY377973 AY377975 AY377976 AY377977 AY377978 AY377979 AY377980 AY377981 AY377982 BC032707 CH471152
GenPept AAF13493 AAH32707 AAR84584 AAR84586 AAR84587 AAR84588 AAR84589 AAR84590 AAR84591 AAR84592 AAR84593 BAG62817 BAG64529 CAC80427 CAC80428 CAC80429 CAC80430 CAC80431 EAW60606
RNA Seq Atlas 22806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca