InnateDB Protein
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IDBP-377425.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NAPRT1
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Protein Name
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nicotinate phosphoribosyltransferase domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390949
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InnateDB Gene
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IDBG-38576 (NAPRT1)
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Protein Structure
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Function |
Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. {ECO:0000269PubMed:17604275}.Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:17604275}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004514
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nicotinate-nucleotide diphosphorylase (carboxylating) activity
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GO:0004516
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nicotinate phosphoribosyltransferase activity
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GO:0016874
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ligase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002638
Quinolinate phosphoribosyl transferase, C-terminal
IPR006405
Nicotinate phosphoribosyltransferase pncB type
IPR007229
Nicotinate phosphoribosyltransferase family
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PFAM |
PF01729
PF04095
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PRINTS |
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PIRSF |
PIRSF000484
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6XQN6
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PhosphoSite |
PhosphoSite-Q6XQN6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
93100
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UniGene |
Hs.493164
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RefSeq |
NP_001273758
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HUGO |
HGNC:30450
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OMIM |
611552
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CCDS |
CCDS69555
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HPRD |
15161
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IMGT |
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EMBL |
AB242230
AY214325
AY214326
AY214327
BC006284
BC032466
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GenPept |
AAH06284
AAH32466
AAP69603
AAP69604
AAP69605
BAF75377
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