Version 5.4
Homo sapiens Gene: NAPRT1
Summary
InnateDB Gene IDBG-38576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPRT1
Gene Name nicotinate phosphoribosyltransferase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147813
Encoded Proteins
IDBP-38578
nicotinate phosphoribosyltransferase domain containing 1
IDBP-377425
nicotinate phosphoribosyltransferase domain containing 1
IDBP-377426
nicotinate phosphoribosyltransferase domain containing 1
IDBP-377430
nicotinate phosphoribosyltransferase domain containing 1
IDBP-813087
nicotinate phosphoribosyltransferase
IDBP-601530
nicotinate phosphoribosyltransferase domain containing 1
IDBP-597741
nicotinate phosphoribosyltransferase domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143574785-143578649
Strand Reverse strand
Band q24.3
Transcripts
ENST00000340490 ENSP00000341136
ENST00000426292 ENSP00000390949
ENST00000449291 ENSP00000401508
ENST00000435154 ENSP00000405670
ENST00000460623 ENSP00000478911
ENST00000498076
ENST00000464332
ENST00000488096
ENST00000480946
ENST00000491904
ENST00000462059
ENST00000529179
ENST00000525583 ENSP00000437102
ENST00000532645 ENSP00000433245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004516 nicotinate phosphoribosyltransferase activity
GO:0016874 ligase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006769 nicotinamide metabolic process
GO:0006979 response to oxidative stress
GO:0009435 NAD biosynthetic process
GO:0019358 nicotinate nucleotide salvage
GO:0019674 NAD metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022574
View Gene Order
ENSBTAG00000014642
Not yet available
Pathways
NETPATH
REACTOME
REACT_11213
Nicotinamide salvaging pathway
REACT_11088
Nicotinate metabolism pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00760
Nicotinate and nicotinamide metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.493164
RefSeq NM_001286829 NM_145201
HUGO
OMIM
CCDS CCDS6403 CCDS69555
HPRD 15161
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca