InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAPRT1

Summary

InnateDB Protein

IDBP-377426.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAPRT1

Protein Name

nicotinate phosphoribosyltransferase domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401508

InnateDB Gene

IDBG-38576 (NAPRT1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. {ECO:0000269PubMed:17604275}.Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17604275}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004516	nicotinate phosphoribosyltransferase activity
GO:0016874	ligase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006769	nicotinamide metabolic process
GO:0006979	response to oxidative stress
GO:0009435	NAD biosynthetic process
GO:0019358	nicotinate nucleotide salvage
GO:0019674	NAD metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR006405 Nicotinate phosphoribosyltransferase pncB type
IPR007229 Nicotinate phosphoribosyltransferase family

PFAM

PF01729
PF04095

PRINTS

PIRSF

PIRSF000484

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6XQN6