InnateDB Protein
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IDBP-377434.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GSDMB
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Protein Name
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gasdermin B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000415049
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InnateDB Gene
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IDBG-46623 (GSDMB)
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Protein Structure
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Function |
May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells. {ECO:0000269PubMed:15010812, ECO:0000269PubMed:18038310}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18038310}. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
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Disease Associations |
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Tissue Specificity |
Expressed in gastric, liver and colon cell lines, carcinomas and non-lesional tissues. {ECO:0000269PubMed:18038310}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007677
Gasdermin
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PFAM |
PF04598
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TAX9
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PhosphoSite |
PhosphoSite-Q8TAX9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55876
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UniGene |
Hs.638861
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RefSeq |
NP_001159430
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HUGO |
HGNC:23690
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OMIM |
611221
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CCDS |
CCDS54120
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HPRD |
17082
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IMGT |
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EMBL |
AC090844
AF119884
AF258572
AK000409
AK296607
BC025682
BX538068
CH471152
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GenPept |
AAF69638
AAG23775
AAH25682
BAA91146
BAG59219
CAD97998
EAW60614
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