Version 5.4
Homo sapiens Gene: GSDMB
Summary
InnateDB Gene IDBG-46623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSDMB
Gene Name gasdermin B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000073605
Encoded Proteins
IDBP-46625
gasdermin B
IDBP-46629
gasdermin B
IDBP-242124
gasdermin B
IDBP-242126
gasdermin B
IDBP-377434
gasdermin B
IDBP-485589
gasdermin B
IDBP-485590
gasdermin B
IDBP-485591
gasdermin B
IDBP-485592
gasdermin B
IDBP-759690
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39904595-39919854
Strand Reverse strand
Band q21.1
Transcripts
ENST00000309481 ENSP00000312584
ENST00000360317 ENSP00000353465
ENST00000394179 ENSP00000377733
ENST00000394175 ENSP00000377729
ENST00000418519 ENSP00000415049
ENST00000479136
ENST00000477054
ENST00000520542 ENSP00000430157
ENST00000523371 ENSP00000429265
ENST00000522564 ENSP00000428217
ENST00000524039 ENSP00000428712
ENST00000486560
ENST00000468820 ENSP00000463519
ENST00000519429
ENST00000464556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 55876
UniGene Hs.306777 Hs.638861
RefSeq NM_001042471 NM_001165958 NM_001165959 NM_018530 XM_005257508 XM_005257510 XM_006721974
HUGO HGNC:23690
OMIM 611221
CCDS CCDS11354 CCDS42313 CCDS54119 CCDS54120
HPRD 17082
IMGT
EMBL
GenPept
RNA Seq Atlas 55876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca