InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HERPUD1

Summary

InnateDB Protein

IDBP-377463.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERPUD1

Protein Name

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Synonyms

HERP; Mif1; SUP;

Species

Homo sapiens

Ensembl Protein

ENSP00000409555

InnateDB Gene

IDBG-32578 (HERPUD1)

Protein Structure

UniProt Annotation

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. {ECO:0000269PubMed:16289116}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10922362}; Multi-pass membrane protein {ECO:0000269PubMed:10922362}.

Disease Associations

Tissue Specificity

Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0006986	response to unfolded protein
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031396	regulation of protein ubiquitination
GO:0032092	positive regulation of protein binding
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044267	cellular protein metabolic process