InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM50

Summary

InnateDB Protein

IDBP-377491.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM50

Protein Name

tripartite motif containing 50

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413875

InnateDB Gene

IDBG-19813 (TRIM50)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. {ECO:0000269PubMed:18398435}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18398435}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt