InnateDB Protein
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IDBP-377494.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ERBB3
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Protein Name
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v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
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Synonyms
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c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000415753
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InnateDB Gene
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IDBG-39824 (ERBB3)
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Protein Structure
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Function |
Binds and is activated by neuregulins and NTAK. {ECO:0000269PubMed:15358134}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
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Disease Associations |
Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. {ECO:0000269PubMed:17701904}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Epithelial tissues and brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
82
[view]
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Protein-Protein |
81
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000494
EGF receptor, L domain
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PFAM |
PF01030
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P21860
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PhosphoSite |
PhosphoSite-P21860
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TrEMBL |
F8VRL0
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UniProt Splice Variant |
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Entrez Gene |
2065
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UniGene |
Hs.622058
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RefSeq |
NP_001005915
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HUGO |
HGNC:3431
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OMIM |
190151
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CCDS |
CCDS44918
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HPRD |
01820
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IMGT |
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EMBL |
AC034102
AK291681
AK295650
AK300909
BC002706
BC082992
BT007226
M29366
M34309
S61953
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GenPept |
AAA35790
AAA35979
AAB26935
AAH02706
AAH82992
AAP35890
BAF84370
BAG58519
BAG62544
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