Version 5.4
Homo sapiens Protein: RAPGEFL1
Summary
InnateDB Protein IDBP-377668.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEFL1
Protein Name Rap guanine nucleotide exchange factor (GEF)-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000394530
InnateDB Gene IDBG-47265 (RAPGEFL1)
Protein Structure
UniProt Annotation
Function Probable guanine nucleotide exchange factor (GEF).
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain
PFAM PF00617
PRINTS
PIRSF
SMART SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHV5
PhosphoSite PhosphoSite-Q9UHV5
TrEMBL F5GYJ3
UniProt Splice Variant
Entrez Gene 51195
UniGene Hs.743875
RefSeq
HUGO HGNC:17428
OMIM
CCDS
HPRD 17954
IMGT
EMBL AC068669 AF117946 AK313492 BC029956 BC115374 BC115375
GenPept AAF22003 AAI15375 AAI15376 BAG36274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca