InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FXYD5

Summary

InnateDB Protein

IDBP-377673.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FXYD5

Protein Name

FXYD domain containing ion transport regulator 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393848

InnateDB Gene

IDBG-43620 (FXYD5)

Protein Structure

UniProt Annotation

Function

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO:0000269PubMed:11756660}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005216	ion channel activity
GO:0045296	cadherin binding

Biological Process

GO:0006811	ion transport
GO:0030033	microvillus assembly
GO:0034220	ion transmembrane transport
GO:0046588	negative regulation of calcium-dependent cell-cell adhesion

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000272 Ion-transport regulator, FXYD motif

PFAM

PF02038

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96DB9

PhosphoSite

PhosphoSite-Q96DB9

TrEMBL

UniProt Splice Variant

Entrez Gene

53827

UniGene

RefSeq

NP_001158077

HUGO

HGNC:4029

OMIM

606669

CCDS

CCDS12447

HPRD

09448

IMGT

EMBL

AB072911 AC002390 AC020907 AF161462 AF177940 AY358991 BC009642 BT007343

GenPept

AAF29077 AAG09301 AAH09642 AAP36007 AAQ89350 BAB83766