Version 5.4
Homo sapiens Gene: FXYD5
Summary
InnateDB Gene IDBG-43620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXYD5
Gene Name FXYD domain containing ion transport regulator 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089327
Encoded Proteins
IDBP-43622
FXYD domain containing ion transport regulator 5
IDBP-246104
FXYD domain containing ion transport regulator 5
IDBP-246106
FXYD domain containing ion transport regulator 5
IDBP-246108
FXYD domain containing ion transport regulator 5
IDBP-377673
FXYD domain containing ion transport regulator 5
IDBP-766057
IDBP-602813
FXYD domain containing ion transport regulator 5
IDBP-601372
FXYD domain containing ion transport regulator 5
IDBP-763777
IDBP-761350
IDBP-760200
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35154730-35169883
Strand Forward strand
Band q13.12
Transcripts
ENST00000342879 ENSP00000344254
ENST00000392219 ENSP00000376053
ENST00000392218 ENSP00000376052
ENST00000392217 ENSP00000376051
ENST00000423817 ENSP00000393848
ENST00000496493 ENSP00000468168
ENST00000541435 ENSP00000443390
ENST00000543307 ENSP00000444839
ENST00000590686 ENSP00000465667
ENST00000592290 ENSP00000465174
ENST00000586925
ENST00000588699 ENSP00000467053
ENST00000591716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005216 ion channel activity
GO:0045296 cadherin binding
Biological Process
GO:0006811 ion transport
GO:0030033 microvillus assembly
GO:0034220 ion transmembrane transport
GO:0046588 negative regulation of calcium-dependent cell-cell adhesion
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009687
View Gene Order
ENSBTAG00000031441
Not yet available
Cross-References
SwissProt
TrEMBL F5H4X8
UniProt Splice Variant
Entrez Gene 53827
UniGene
RefSeq NM_001164605 NM_014164 NM_144779 XM_006723245
HUGO HGNC:4029
OMIM 606669
CCDS CCDS12447
HPRD 09448
IMGT
EMBL AC002390 AC020907
GenPept
RNA Seq Atlas 53827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca