InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF17

Summary

InnateDB Protein

IDBP-377676.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF17

Protein Name

PHD finger protein 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000404211

InnateDB Gene

IDBG-37885 (PHF17)

Protein Structure

UniProt Annotation

Function

Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. {ECO:0000269PubMed:15502158, ECO:0000269PubMed:16046545, ECO:0000269PubMed:16387653}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. {ECO:0000269PubMed:12169691, ECO:0000269PubMed:16046545}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0030308	negative regulation of cell growth
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019542 Enhancer of polycomb-like, N-terminal
IPR019787 Zinc finger, PHD-finger

PFAM

PF10513
PF00628

PRINTS

PIRSF

SMART

SM00249

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6IE81